Sentence examples for be devoid of activity from inspiring English sources

The compounds are selective upstream inhibitors of FcεR1-dependent human mast cell degranulation and proved to be devoid of activity in downstream ionomycin mediated degranulation.

Lead compounds in this series were found to be devoid of activity at the dopamine transporter and were shown to be brain penetrant with high receptor occupancy.

Glutathion Reductase was found to be devoid of activity whatever reducing co-substrate was used (1 mM NADPH or 33 µM DteT).

First, an in vitro receptor binding study showed that CHIBA-1001 is a highly selective ligand at α7 nAChRs, since this ligand was found to be devoid of activity for the standard receptor binding profile.

Furthermore, CHIBA-1001 (1 µM) was found to be devoid of activity (inhibition lower than 50%) for a 28 standard receptor binding profile (See Supplemental Table S1 and S2).

SSR180711 displaced specific binding of [3H]α-bungarotoxin to the rat and human α7 nAChRs with Ki values of 22 and 14 nM, respectively [23], and SSR180711 (10 µM) was found to be devoid of activity (inhibition lower than 50%) for a 100 standard receptor binding profile [23].

While the parent compound is devoid of activity, both metabolites of fexinidazole are active against intracellular L. donovani amastigotes.

As expected, mutants Q43X and S19fsX51, which produce truncated forms of receptor, were devoid of activity.

Conversely, analogous monocarboxy caffeoyl analogs exhibited only modest inhibition, while the corresponding 3,4-dihydroxybenzoyl-substituted compounds were devoid of activity.

Because the mutant of Arg295 to an alanine is devoid of activity, this loop likely undergoes an induced-fit conformational change upon substrate binding and product dissociation.

The molecules are devoid of activity at the GlyT2 isoform and display excellent selectivities against the μ opioid receptor as well as the nociceptin/orphanin FQ peptide (NOP) receptor.