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As for active sites of enzymes, cryocooling should increase the fraction of ligands bound at the cryptic sites, which creates a potential advantage for identifying weak cryptic-site binders that can be developed to affect allosteric responses.
This raises the hope that therapeutic agents may be developed to affect the balance between SCD and ACD in tumour-initiating cell populations and cancer stem cells in order to modulate cancer malignancy and improve clinical outcome.
Several of these would modify inflammation or oxidative stress by one mode of action or another while others could be developed to affect implantation and survival of endometriosis implants or to mitigate some of the actions of cellular mediators of endometriosis associated inflammation.
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strategies to be developed to rehabilitate soils affected by increased levels of salinity.
In order to improve the reliability of results, worker productivity instruments should be applied to assess presenteeism [ 32] and easy-to-use questionnaires should be developed to determine how employee presenteeism affects profit.
A Kansei mining system is developed to utilize valuable affect information latent in customers' impressions of existing affective designs.
Other bots are currently being developed to help people affected by gang violence in Brazil and H.I.V. in Nigeria.
Under some mild conditions, an adaptive robust fault-tolerant control is developed to compensate the affects of uncertainties, actuator failures and errors caused by quantization, and a range of the parameters for these quantizers is established.
Additional mouse models have been developed to test genes affecting tumorigenesis in mice with Apc mutations.
Root system development was monitored in greenhouse-grown potato while a root-on-a-plate assay was developed to explore factors that affect AR and LR development.
Proposed mathematical model is developed to predict particle size affected by different parameters and validated with experimental results.
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