Several annotation pipelines have been developed for functional analysis based on sequence, 'omics', and literature data.
For example, novel PET markers of tumour hypoxia or proliferation have been developed for functional characterization of various tumour entities.
This protocol was developed for functional imaging studies and was subsequently introduced in the outpatient clinic of our hospital.
Although sequence assembly and gene prediction tools specifically developed for metagenomic data sets offer some advantages over similar tools developed for more complete genome sequences, surprisingly, no such 'metagenome specific' tools have yet been developed for functional analysis.
Although prediction models have been developed for functional decline or disability in older people who were hospitalised because of specific medical conditions, to our knowledge, this is not the case for community-dwelling older people [ 19].
The database was developed for functional prediction of all potential nonsynonymous single-nucleotide variants in the human genome and compiles prediction scores from prediction algorithms including SIFT (Human_db_37_ensembl_63), Polyphen2 (v2.2.2), MutationTaster (retrieved 2012), and FATHMM (v2.1).
The go/no-go task employed in this study was developed for functional magnetic resonance imaging by Casey et al. (1997), who reported increased prefrontal cortex activity during response inhibition.
Several tools have been developed for functional studies of the basic unit of life; however, transcriptomic analysis was developed using microarray chip technology and mutational analysis and focuses on identifying the genes/regulators/regulons involved in the growth phase transition from primary to secondary metabolism in S. coelicolor [ 105].
This would perhaps allow more targeted and accurate sampling methods to be developed for fewer taxa representing functional guilds while improving statistical power and overall robustness in non-target assessment.
Matched pairs of luminal and myoepithelially derived lines can also be developed for further investigation of normal functional interactions.
