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Nevertheless, the exact contribution of point mutations can not be determined with respect to the physiological activities and pathogenicity.
Difficulties in the development of neutralizing vaccines are most likely accounted for by the high diversity of A. salmonicida strains and mechanisms of pathogenicity, which can be determined with various factors including type three secretion system, A layer protein, lipopolysaccharide, iron binding and outer membrane proteins, peptidases and toxins of different nature (reviewed in [ 2, 11]).
The Spanish influenza exemplifies how the magnitude of a pandemic can be determined by the pathogenicity of the virus.
The phenotypic variation associated with each variant must be determined as distinct from pathogenicity.
Instead, the pathogenicity of these factors might be determined by their expression.
The viruses were selected based on their previously described pathogenicity, which was determined per their pathogenicity index (PI) in DBA/2J mice.
The pathogenicity of 3 subtype H5N1 viruses (the 2 H5N1/H9N2 7:1 reassortants and the H5N1 A/chicken/Bangladesh/12VIR-7140 12/2012 isolate) was determined by intravenous pathogenicity index in specific pathogen free chickens.
More severe pathological consequences of H. pylori infection are determined by the cag pathogenicity island, and only strains containing cag pathogenicity island activate NF-κB proinflammatory cytokines [ 105].
The specific functional role of this deletion in H9N2 viruses needs to be determined but there was no evidence of any increased pathogenicity associated with the deletion in our IVPI tests.
The 50% mouse lethal dose was determined to assess the pathogenicity of the buzzard influenza (H5N1) virus in mammals.
Whether WUPyV or KIPyV have oncogenicity or other pathogenicity in immunocompromised hosts remain to be determined.
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