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This may be determined by randomized controlled trials or meta-analyses.
However, the true value of HDAC inhibitors in this kind of epigenetic combination therapy can only be determined by randomized trials.
Ultimately, the cause and effect of template-items on care delivered can only be determined by randomized controlled trials which would be an important future step in efforts to optimize care.
Disentangling the additional benefit of DUP reduction on the early outcomes of FES care would ideally be determined by randomized allocation of ED vs. no-ED within a single sample that would all subsequently receive the same FES care.
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The optimal treatment of TBM has not been determined by randomized controlled trials, although a number of clinical guidelines exist [5] [7].
The clinical benefit of statin therapy in sepsis remains to be determined by ongoing randomized controlled trials.
Whether one treatment is superior can only really be determined by further randomized studies.
Whether these agents will improve median OS in unselected patients will be determined by ongoing, randomized phase 3 trials.
Whether cytokine determination and genotyping in critically ill patients could optimize treatment and sepsis outcome should be determined by further randomized studies.
The utility of this molecule in treating platinum-resistant disease will hopefully be determined by a randomized, double-blinded, placebo-control study examining paclitaxel with and without concurrent MORAb-003 (NCT00738699).
The effect on sensitivity and recall rates of radiologists using this interactive CAD system for real-life screening can only be determined by a large randomized controlled trial in which radiologists use this system during routine use and for a substantial period [ 17].
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