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Here the model can be used to take the effect of case clustering into consideration in calculating the minimum difference in an outcome variable (e.g. disease prevalence) that can be detected with statistical significance.
The minimum difference that can reliably be detected with statistical analyses is determined by the number of replications of each treatment, n, the variance of the data and the number of treatments applied.
Teshima et al. (5) showed that such signals are sometimes too subtle to be detected with statistical significance in a genome scan.
As very large numbers of cases and controls are now included in genome-wide association studies, more and more loci are found to show associations, and loci with low effect sizes (under 1.5) start to be detected with statistical confidence.
Numerous methods are available for detecting gene-gene interactions [ 24- 26], each of which has been designed with different assumptions of how biological interactions can be detected with statistical methods.
We also applied this statistical method to detect somatic mosaicism in patients with known low-level mosaic mutations described above and confirmed that all of the mutations could be detected with statistical significance without any false positives (data not shown).
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The cell fate-dependent inhibition was detected with statistical confidence in all the phytohormones.
Low copy number of a region corresponding to a genomic variant (Variation_7105) located at 16p11 nearby the centromere was detected with statistical significance at much higher frequency in patients from ICCA families than in ethnically matched controls.
A total of five GO terms were detected with statistical overrepresentation (fig. 7 F).
Consequently, only pathways enriched in individual differentially expressed genes are detected with statistical significance.
Allelic imbalance was detected with statistical significance for the SNP rs1042719 andB2 and the SNP rs1433099 LDLR by both methods.
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