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Abundance of ABTS+ molecules were produced, a single smaller molecule ABTS+ may not be detected using our solid-state nanopore, due to the resolution of the system [3].
This rapidly dissociating side-binding of AIP1 would not be detected using our current experiment setting.
We note that some of the miRNA targets predicted by the analysis could only be detected using our proteomics data, while others were only identified using the transcriptomics data.
The low number of F-box proteins detected in apicomplexan parasites could indicate that there is no need for these specific adaptors, or that their amino acid sequences are highly divergent from other eukaryotic cells and could not be detected using our standard HMM search.
An extremely recent selective event in these populations would not be detected using our approach.
Pleasing lower concentrations of c-di-AMP (down to 5 μM) could be detected using our system (see Figure 5a).
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MiRNAs expressed in liver were detected using our miRNA-array.
Potential turn-forming elements were detected using our software tool SVMTurn (www.modlab.deSoftwareSVMTurn) [33].
Re-investigation of the raw SNP data for LAU-T50B showed that there was indeed a small amplification signal at MDM2, but this had not been detected using our optimization parameters (see Methods S1).
All previously identified genetic variants were detected using our method.
miRNA expression profiles of 63 ICCs and nine NIBD were detected using our custom miRNA microarray.
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