Such a magnitude of difference is large and can be detected using other methods such as low-order polynomial fitting.
To verify the capability of L-band InSAR when applied to volcano monitoring, we performed InSAR analyses using improved processing algorithms (Fujiwara et al. 1998; Tobita et al. 1998) to discover magmatic crustal deformation that could not be detected using other geodetic techniques.
Although Dmpk−/− and Six5−/− showed no overt anxiety phenotype in the open field, we performed only one test of anxiety and thus subtle phenotypes may exist that can be detected using other tests.
CHAP works best when sequences are available from many species, because even if a conversion cannot be detected using one particular primary or outgroup species (e.g. due to difficulty assigning orthologs), it may still be detected using others.
This is relevant as exemplified by patient P3 in our series, who showed a rare oncogenic GNA11 mutation (c.626A>T [j] 627G>A) that may not have been detected using other methods.
As QTL identified using MIM were robust and supported by SIM results, it is unlikely that additional large effect QTL involved in epistatic interactions might have been detected using other QTL mapping methods that detect both main effect (M-QTL) and epistatic QTL (E-QTL).
As the Venn diagrams of the sample level analysis clearly illustrate, it is hard to define a true gold standard when all modalities used seem to miss some positives that are detected using other modalities; however, Fig. 1b illustrates that PCR testing will result in the highest detection rate of patients with a positive immunoassay, PCR or toxigenic culture.
While we were unable to analyse the insoluble material that remained following extraction of cartilage tissue (and therefore could not quantify total differences in protein abundance), our method was especially useful in allowing us to identify subtle differences in the extraction of individual protein oligomers that may not have been detected using other methods.
High-expression of some of these genes has been detected using other experimental approaches, including RT-qPCR (e.g. [ 42, 43]), supporting the conclusion that the ultra-high expression that we report for these genes reflects the biology of the mammary gland in late pregancy and lactation and is not an experimental artifact.
Previously, non-neoplastic esophageal epithelial cells from ESCC patients were reported to have shorter mean telomere length than esophageal cells from non-cancer patients [ 29], suggesting the presence of a telomere-shortened epithelial field that could potentially be detected using balloon cytology or other analogous methods.
We note that some of the miRNA targets predicted by the analysis could only be detected using our proteomics data, while others were only identified using the transcriptomics data.
