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Purpose Hyperpolarized (HP) 129Xe gas in the alveoli can be detected separately from 129Xe dissolved in pulmonary barrier tissues (blood plasma and parenchyma) and red blood cells (RBCs) of humans, allowing this isotope to probe impaired gas uptake.
PURPOSE: Hyperpolarized (HP) (129) Xe gas in the alveoli can be detected separately from (129) Xe dissolved in pulmonary barrier tissues (blood plasma and parenchyma) and red blood cells (RBCs) of humans, allowing this isotope to probe impaired gas uptake.
Hyperpolarized (HP) (129 Xe is a promising surrogate for these metabolic gases, because MR spectroscopy and imaging allow gaseous alveolar (129 Xe to be detected separately from (129 Xe dissolved in the red blood cells (RBCs) and the adjacent tissues, which comprise blood plasma and lung interstitium.
After a single injection, the emerging (129 Xe gas could be detected separately from (129 Xe remaining in the blood and was imaged with an in-plane resolution of 1 x 1 mm and a signal-to-noise ratio of 25.
As expected, the ~400- and 120 kDa sized proteinases could be detected separately from each other by densitometry when albumin and goat IgG were tested).
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HP 129Xe displays a reasonably high Ostwald solubility in many tissues [12], including the blood (∼14%), and exhibits an unusually large, environmentally dependent nuclear magnetic resonance (NMR) chemical shift range (>200 ppm in vivo) that allows dissolved 129Xe to be excited and detected separately from gas-phase 129Xe [8].
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