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Menrad et al (1993) have been the first to describe the presence of CD13 on melanoma cells, whereas CD13 expression could not be detected on normal melanocytes.
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Only alpha 2, alpha 3 and beta 1 were detected on normal transitional cell epithelium, but four TCCs (12.5%) revealed positive staining for alpha 1, seven (19.4%) for alpha 4 and seven (20%) for alpha 5.
Using an in vitro model system representing various stages of breast oncogenesis, LEA.92 was detected on normal or immortalised mammary epithelial cell (MEC) lines which were dependent on epidermal growth factor (EGF) and anchorage formation for growth and non-tumorigenic in nude mice.
Because of the coupling influence, the transient voltage and current can also be detected on the normal line.
Low affinity but saturable binding can also be detected on hTert-immortalized, normal oral keratinocytes (unpublished data), and preliminary data suggest that the highly glycosylated virus membrane protein gp150 may be involved [19].
We observed that β-HPV DNA is prevalent in EGLs (61.1%) and that most viral DNAs are detected on the normal genital skin before EGL development [ 7].
Four U3 lesions were detected on US with normal mammograms, one of which was malignant.
While CAIX appears at malignant transformation and stains positive in about 95% of clear cell RCC specimens as well as in most renal cell metastases, no CAIX was detected on the surface of normal adult or fetal tissues except its cytoplasmic expression in the epithelium of the bile ducts and small intestine together with the mucous cells of the gastric epithelium [16].
No organomegaly was detected on ultrasound scans or normal echocardiogram.
Fas was detected on the surface of normal breast cells and T47D and MCF-10A cell lines but only intracellularly in other breast cell lines tested.
LEA.92 was detected on the surface of normal but not malignant epithelial cells, which included breast, cervix, colon, lung, pancreas and stomach.
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