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Of the thousands of miRNAs described to date in humans, many exhibit tissue-specific patterns of expression can be detected in circulating blood.
Many different types of miRNAs can be detected in circulating blood, and these miRNAs are present in a remarkably stable form that even withstand repetitive freezing/thawing cycles and are protected against RNases.
In up to 25% of healthy blood donors C. pneumoniae can be detected in circulating monocytes by PCR or culture [22].
This observation is consistent with previous findings that HNE gene is mainly expressed at the promyelocytic stage of granulocyte development, and mRNA cannot be detected in circulating neutrophils [10], [11].
These methods indeed suggested a number of potentially new biochemical markers of preterm labor [ 32], some of which, for example, could be detected in circulating immune-cells.
Recent advances have demonstrated that some miRNAs can be detected in circulating blood and that these circulating miRNAs might therefore be useful as disease biomarkers [ 8].
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Although we and others [ 35, 46, 47] have described clonotypic B cells in the circulation of MM patients, and chromosomal abnormalities have been detected in circulating MM B cells, there have been few reports characterizing BM-lymphocytes with respect to clonal characteristics shared with MM-PC.
In PD, some biochemical alterations affecting neuronal cells have been detected in circulating lymphocytes.
Both mutations have been detected in circulating cell-free DNA (CFDNA) from asymptomatic HBV carriers.
Low expression of TREM-1 at the cell surface has also been detected in circulating CF-MΦs [ 7].
No significant differences were detected in circulating white blood cells, lymphocytes, granulocytes, or monocytes, regardless of the uranium exposure level.
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