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Thus their occurrence in dissimilar domain contexts, provided homology can be detected by sequence or structural similarity, forms the basis of evolutionary domain definition.
2) Sequence domains are regions of polypeptide chain that can be detected by sequence similarity and can be found in combination with other sequence domains.
Interestingly, similar divergence trends of human let-7/let-7* could be detected by sequence analysis across vertebrates (Figure 3), which might reveal historical miRNA gene divergence and similar evolutionary trend across different animals.
Homologs of this terminator cannot be detected by sequence similarity even across close relatives (see Additional file 1, Section 5).
The genetic causes of hearing loss can be detected by sequence analysis, which helps clinicians and patients to delineate the basis of the disease.
Thus, nonhomologous proteins that share a common structural topology will most likely represent an ancient evolutionary relationship that is too distant to be detected by sequence similarity [ 25].
Similar(47)
The 3′ cleavage remnants from the target transcripts are relatively stable in vivo, and could be detected by sequencing.
Since sequence-specific TFs possess DNA-binding domains (DBDs) to recognize specific motifs in miRNA promoter sequences, potential binding sites can be detected by sequence-based computational approaches, for example, position weight matrix (PWM).
Alternatively, barcodes can be detected by sequencing.
Methylation down-regulates expression of local genes and can be detected by sequencing bisulfite-treated DNA [ 29].
In three samples no mutation could be detected by sequencing analysis, while HRM showed an abnormal melting profile which is indicative of the presence of a mutation.
More suggestions(15)
be classified by sequence
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be explained by sequence
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be mediated by sequence
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be confounded by sequence
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