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However, a proportion of CTC antigen expressions are down-regulated or lost in the process of epithelial-mesenchymal transition (EMT), and thus, this part of CTCs cannot be detected by classical detection methods such as CellSearch.
Therefore, these analogous enzymes cannot be detected by classical comparative genomics approaches, as they do not share any detectable sequence similarity.
These objects may be detected by classical methods like sliding window.
This phenomenon leads to a situation where small objects are hard to be detected by classical methods.
This type of panel gives access to new varietal group-specific QTLs that cannot be detected by classical mapping in indica x japonica populations.
In particular, composite structures may be subjected to internal damages caused by external impacts that may not be detected by classical inspection methods.
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Second, small gene mutations have been detected by classical Sanger sequencing [ 17- 22] or, more recently, by the use of new technologies such as next generation sequencing (NGS) [ 23- 31].
Breast cancer is generally no longer curable once metastases are detected by "classical" means: clinical manifestations of the spread, imaging methods, and serum marker assays, such as those based on carcinoma antigen 15-3 (CA 15-3) or carcinoembryonic antigen (CEA) [ 56].
These mechanisms are activated at BPA concentrations below the concentration range in which "pharmaceutical" effects are detected by classical toxicology and generate nonmonotonic dose response curves such as inverted U- or U-shaped curves.
Preliminary experimental results over members of the RNAs P and Hammerhead families show that the tool can be used for detecting new structural similarities between RNA molecules, which could not be detected by the classical rooted-ordered tree alignment methods.
Given the low stringency of the polyhema growth selection on MDCK cells, which did not reduce the repertoire of library-derived transcripts detected by the xenoarray after the selection, it is likely that many of the above-described hits provide only a limited advantage, and could not be detected by a classical approach based on more drastic selection strategies.
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be generated by classical
be detected by statistical
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