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This method is limited in that a host strain or an experimental setup must be designed that does not enable the host to grow unless the desired activity is present.
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Can GLP-1R agonists be designed that do not increase heart rate?
We suggest a literature search for known splice variants of a particular gene to be completed so that primers or probes can be designed that do not span exons which may be affected by alternative gene sequences.
In the future, with the use of X-ray crystal structures of the transporters, inhibitors can be designed that do not bind to transporters and overcoming these challenges should allow structure-based design an even greater impact on drug discovery.
The chief benefit of low-coherence interferometry is that systems can be designed that do not suffer from the 2 pi ambiguity of coherent interferometry, and as seen in Fig. 18, which scans a 180μm x 140μm x 10μm volume, it is well suited to profiling steps and rough surfaces.
Two-stage phase II trials for assessing survival probabilities can be designed that do not require prolonged suspension of patient accrual.
The coefficients for (b) and (c) were designed that the marker did not to go out of the image of the dump when moving at the maximum speed.
"There are very few homes that are designed here that do not have at least one," said Peter Handler, general manager of the Wolf Corporation, a custom builder in the city.
The result is a design that does not infringe Cisco's patent and is more efficient to boot.
Its distinctive feature is a design that doesn't simply invite a user to pay attention to an ad — it also compels attention.
"I don't know if it's designed to do that, but it will do that".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com