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Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of reprogramming transcription factors.
In recent years, ESCs can also be derived from somatic cell nuclear transfer embryos (ntESCs), parthenogenetic embryos (pESCs), and androgenetic embryos (aESCs).
It should also be noted that some of these differences may be derived from somatic mutations as the DNA used for sequencing was derived from young leaves two weeks after germination.
With regard to cell replacement, IPSCs have the distinct advantage that they can be derived from somatic cells such as skin fibroblasts from essentially any donor subject for reintroduction to that same individual as an autologous transplant.
Pluripotent, self-renewing cell lines, called induced pluripotent stem cells (iPSCs), can also be derived from somatic cells by transient ectopic expression of transcription factors that are normally expressed in ESCs (Takahashi and Yamanaka, 2006).
The remaining five appeared to be derived from somatic events because the identical insertion occurred in more than one fly, meaning that one parent was a germline mosaic and had the same insertion present in many but not all germ cells.
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If NT-1 is derived from somatic cell nuclear transfer, all 48 polymorphism markers must be identical between the donor B cells and NT-1 cells.
In addition, the development of induced pluripotent stem cells, which are derived from somatic cells that have been reprogrammed to an embryonic state through the introduction of specific genetic factors into the cell nuclei, has challenged the use of cloning methods and of human eggs.
In somatic embryogenesis, a plant or embryo is derived from somatic cell(s) and somatic embryos are formed from plant cells that normally are not involved in the development of embryos (Bajaj 1995).
Within the field of cardiac engineering, induced pluripotent stem cells (iPSCs) are an exciting tool that offer the potential to advance the current state of the art, as they are derived from somatic cells, enabling the development of personalized medical strategies and patient specific disease models.
It is a recent discovery that iPSCs are derived from somatic cells through ectopic expression of specific transcription factors [ 25].
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