Cui and co-workers compiled a selective list of 284 cancer mutated genes which were derived from large scale sequencing and the literature (Supplementary Table S10 in [ 12]).
Such contextual information can be derived from large-scale data on interactions (i.e. physical, genetic, co-expression) between genes or gene-products, such as proteins.
The former one is derived from large-scale cross-linguistic data, and it not only shows how the different functions are connected in a particular language but also reflects how these functions are connected in the conceptual level.
In summary, the sample was derived from large-scale population studies of the epidemiology of obstructive airway diseases in Northern Sweden, the OLIN studies.
Given that the vast majority of publicly available sequence data from complex genomes is derived from large-scale partial gene sequencing projects, it would be a serious handicap to limit phylogenetic analyses to alignments derived only from full-length sequences.
Concerning the "characterized" genes, it can be noted that the function of many annotated genes is derived from large-scale studies, and hence, in-depth detailed analysis is lacking for these genes.
The rate of false negatives on the other hand, limits the extent of information that can be derived from a large-scale screen for any biological process.
A total symptom score will be derived from this scale.
Participants were instructed to answer on an 8- point scale ranking ("0 = I do not agree at all" to "7 = I agree fully"), instead of the proposed 5-point scale because it was determined in the pilot study that more precise results would be derived from the use of a larger scale.
It is expected that the correct model of heat conduction at both short and large scales could be derived from the Boltzmann transport equation under the relaxation time approximation [6].
Notwithstanding the above potential limitations, this study suggests that disease signatures derived from large scale analysis of blood samples from psychiatric patients may exist and could be detected by using large and well characterized sample sets.
