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Aurora-A kinase has recently been shown to be deregulated in thyroid cancer cells and tissues.
As miRNAs have been reported to be deregulated in thyroid cancer [ 18], and they have been shown to function both as tumor suppressors and oncogenes [ 19], we decided to assess the prediction value of two miRNAs targeting the KIT gene; namely, miR-146b and miR-222.
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CDK family members have attracted widespread attention as potential oncogenes and are widely reported to be deregulated in many cancers.
Comparison of the pattern of deregulated MS miRNAs with miRNAs previously found to be deregulated in other human diseases showed a remarkably high percentage of miRNAs (74%) that are deregulated in MS but not in any other disease.
In addition, miR-220 is also reported to be deregulated in leukemia [42]; miR-24-2 is deregulated in colon cancer [38], stomach cancer [38], and liver cancer [43].
Many miRNAs are known to be deregulated in cancer [ 6].
It appears that these processes may be deregulated in BEN.
Our results help shed light on radiation-induced thyroid carcinogenesis, since specific molecular pathways are deregulated in radiation-induced tumors.
In fact, the expression of miRNAs was deregulated in many human cancers, including leukemia, lymphoma, and glioblastoma, as well as colon, lung, breast, prostate, thyroid, cervical, and ovarian cancers [58]– [58].
In response to pressure by struggling station owners, commercial radio was largely deregulated by the FCC in the late 1970s, and public stations were deregulated in the mid-1980s.
Expression of matrix metalloproteinase-9 is deregulated in numerous wound healing pathologies.
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