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However, the relationship between low neurotransmitter levels and symptomatology is not simple and may be dependent on genetic background [ 1].
It is interesting that the incidence of mammary tumors in Trp53-deficient mice appears to be dependent on genetic background strain [ 23].
At least some of these effects seem to be dependent on genetic strain of the model system, means of administration and length of treatment [ 6, 17, 18, 23, 24].
Altered levels of production of this cytokine may be dependent on genetic and/or epigenetic mechanisms [ 85], and its blockade therefore is a logical therapeutic target for the treatment of SS.
Notably, effects of sex hormones in EAE have also previously been shown to be dependent on genetic background [ 72] and some autosomal gene linkages to susceptibility to MS have been identified in one gender but not the other [ 73].
The association of ZFAT with height is replicated in a study of 1,077 Franches-Montagnes horses [ 25], suggesting the effect of the size QTL near ZFAT may be dependent on genetic background.
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Using an REML approach we were able to quantify the extent to which phenotypic variation in mating speed was dependent on genetic identity of one or both sexes.
Our data indicate that the role of 5-HT1A receptor activation on anxiety-related responses is dependent on genetic background and selected paradigm used to assess anxiety.
The adaptability of trees to new conditions is dependent on genetic diversity, which is largely controlled by population size, the nature and direction of observed climate change, and the direction and intensity of selection (Alberto et al. 2013).
All of these ecological traits are dependent on genetic and environmental factors.
It is known that adult β-cells exhibit limited proliferation capacity that is dependent on genetic background [5], [6], [7].
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