According to our analysis, the catalytic domain of this family is highly flexible and thus the formation of a druggable cavity is dependent on conformational rearrangement.
Solution of the time-dependent probability distributions shows that the overall rate is dependent on conformational dynamics whose time scales are similar to or slower than that of the chemical step.
Previous studies have demonstrated that KCNN4 channels belong to the Ca2+-activated potassium channel superfamily, and the activation of these channels is dependent on conformational changes in calcium calmodulin [ 18].
However, it is well established that molecular alignment in ordered media is dependent on conformation, and slowly interconverting conformational substates may exhibit different alignment properties.
It is also possible that the slow gating in hERG might be dependent on turret conformational changes.
This pocket is covered by the sidechains of residues Asp94, Arg145, Arg148 and Asp149 (Fig. 3b), the resorcinol molecule diffusing in or out of the binding pocket must be dependent on certain conformational changes of these residues' sidechains.
The aggregation characteristics of α-synuclein appear to be dependent on the conformational state of the monomeric protein; 10 thus, the complex interplay between binding and folding is directly relevant to the disease aspects of the protein.
Accessibility of RNase II to its binding site would be dependent on a conformational change induced by RhlB binding and, perhaps to a lesser extent, by PNPase binding to the RNaseE scaffold domain.
In the case of proton-driven secondary transporters, these pathways must also be dependent on the conformational state of the protein, that is, they must be consistent with an alternating-access mechanism, so as to preclude leakage and ensure strict coupling of substrate and proton transport.
Our data so far suggest that P-body formation may not be dependent on amyloid-like conformational changes.
