The least squares means (LSM), i.e., means adjusted for the covariates in the model, of the treatment contrast for indacaterol 150 μg versus placebo was estimated along with the associated 95% confidence interval and two-sided p-value, and superiority of indacaterol over placebo was demonstrated only if the p-value was less than the pre-specified 5% significance level.
It appeared that the South's disregard of Supreme Court rulings on interstate transportation could be dramatically demonstrated only if the Freedom Riders who integrated bus stations were met with violence — whether the violence was described by Southern politicians as "looking for trouble" or by nonviolent theoreticians as "cleansing the soul with blood".
Thirdly, although the rate of ICD implantations was low within the follow-up of 36 months, a meaningful benefit with regard to all-cause mortality could only be demonstrated if ICD implantation was performed relatively late after acute MI, but not early after acute MI.
The eventual impact of these initiatives will only be demonstrated if there is a fall in disease-specific mortality rate.
First of all, product efficacy can only be demonstrated if the satiety-enhancing product concepts can actually be technologically produced without compromising (too much) on taste, convenience, and price.
If adequate control cannot be demonstrated, authorisation may only be granted if it is shown that socio-economic benefits outweigh the risks (article 60(4)).
Suggestions were made that she lacked passion, as if passion could only be demonstrated through red-faced screaming at baying crowds.
In this subsequent study, superiority is concluded only if it can be demonstrated.
An accurate stratification during study recruitment with regard to 'progressors' with relatively rapid cartilage loss is, however, important, because the potential therapeutic effect of a disease-modifying OA drug can be demonstrated using much lower sample sizes if only participants with a high likelihood of fast progression are recruited.
