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Enhancement of marrow toxicity could be demonstrated only at CCNU doses greater than 12.5 mg/kg, so that at lower CCNU doses there was a therapeutic gain equal to the tumour enhancement ratio.

Complete inhibition of some isolates was demonstrated only at very high concentrations of 2 4 g L−1.

Biohydrogen production has been demonstrated only at the laboratory scale, and the yield of H2 from any of the tested processes is still low for commercial application.

(Dexrazoxane, a hexadentate chelator, is also marketed [ 1686].) *Nephrotoxicity that has been observed in non-iron-loaded animals has been minimal in iron-overloaded humans, but effectiveness is demonstrated only at higher end of tested doses, as discussed in [ 1693].

Efficacious IFN inoculation was demonstrated only at the lower dose of 200mg total DNA, as previously described (5), while the dosage of 400mg total DNA suppressed the efficacy associated with individual administration of these IFN subtypes.

There was no significant effect on SAP, CI (Fig. 1) or calculated SVRI (Fig. 2) with any dose of dopamine, PAP was elevated at all doses, and a significant increase in calculated PVRI was demonstrated only at 10 μg kg-1 min-1 dopamine.

In contrast, when the post hoc power calculations were performed for the brush allodynia measurements, the sufficient power values (i.e., power value more than 0.8) were demonstrated only for the measurements taken at HA1 (160 min), HA2 (200 min) and HA3 (240 min) study drug or placebo administration (power values of 0.815, 0.805, 0.801, respectively).

A radiation-induced blood brain barrier (BBB) breakdown has been supposed to explain the acute radiation syndrome and the delayed brain radiation injury, but it has been clearly demonstrated only at high doses.

In addition, a nitrite electrocatalytic effect was also demonstrated only at CNF/hemin/GC modified electrode, showing an extended linearity (ranging from 5.0 × 10−3 to 2.5 × 10−1 M), a lower detection limit (L.O.D. = 3σ) of 3.18 × 10−4 M, a higher sensitivity of 1.2 × 10−2 A M−1 cm−2, a fast response time of 10 s, a good reproducibility (RSD% <1, n = 3) and finally a good operational stability.

For example, the antimicrobial activity of hBD-2 can only be demonstrated at low salt conditions [51], at least in low micromolar concentrations.

In the present study no significant association between pneumonia and peritonitis could be demonstrated at necropsy and only M. haemolytica and E. coli could be isolated from peritoneal fluid.