A similar antagonism has been demonstrated in normal and DM1 myoblasts between the complex made of hnRNP H and CUG-BP1, and MBNL1, during exon 11 selection in IR splicing [22].
The fear-reducing effects of CORT in HAB subjects can be explained by its ability to inhibit the recall of previously acquired, emotionally arousing information [66], [67], [68], [69], [70], [71] – an ability that has so far been demonstrated in "normal" animals [72], [73], [74], [75] and in humans with PTSD or phobias [30], [32], [61].
This has also been demonstrated in normal cells forced to have a double complement of DNA and centrosomes: retinal pigmented epithelial (RPE1) cells treated with a cytokinesis inhibitor are able to cluster the centrosomes to form a bipolar spindle and proceed through the cell cycle [4].
Seventeen bands of gangliosides were demonstrated in normal human leucocytes.
Indeed, FoxP3 expression has been demonstrated in normal and neoplastic epithelial cells.
It must be noted, however, that the mechanistic proof was demonstrated in normal tissue, not in the tumour.
Duct wall enhancement alone may not be a predictor of tumor involvement, and has been demonstrated in normal subjects [ 39].
Impaired endothelial vascular function has been demonstrated in normal tension glaucoma (NTG) and other glaucomas [ 3, 21, 31– 31].
The effects of IGF-1 on increasing insulin sensitivity have been demonstrated in normal subjects during euglycemic clamps (13).
