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There is unresolved controversy about whether direct carcinogenic effects of some oestrogen metabolites, which can clearly be demonstrated in model systems, also have a significant impact in women.
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In vivo, the suppressive activity of adoptively transferred MDSCs could be demonstrated in models of inflammation [49] and cancer [50].
In various in vivo studies a neuroprotective effect in terms of post-ischaemic cerebral damage reduction could be demonstrated in models of transient [ 40- 44] but not permanent [ 45] focal ischaemia.
Hence, removal of senescent cells is beneficial and has been demonstrated in model animals [ 84].
It has been demonstrated in models that coevolutionary clines may result from multiple effects [68].
The cost-effectiveness of nab-paclitaxel in MBC has also been demonstrated in model-based and retrospective analyses [ 22, 23].
It has been demonstrated in models of inflammation that the mechanisms of quercetin are related to inhibition of oxidative stress and cytokine production [ 23, 24].
Clumping factor B (ClfB) mediates respiratory infection and attachment to cytokeratins on nasal epithelial cells [ 42] and the role of protein A (Spa) in S. aureus virulence has been demonstrated in models of sepsis and pneumonia [ 43].
This beneficial effect could be demonstrated in animal models of HFOV.
Can it be demonstrated in mouse models of cancer, progeroid syndromes, metabolic derangements and neurodegenerative diseases?
Likewise, immunotoxicity of PFCs has been demonstrated in rodent models, avian models, reptilian models, and mammalian and nonmammalian wildlife [ 19].
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