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For example, MMPs can be deleterious in some diseases, such as OA, but they may protect the body in others [ 4].
However there is clinical equipoise around this intervention because the benefit has not yet been demonstrated in a robust prospective clinical trial, and several observational studies have suggested sodium lowering interventions may be deleterious in some dialysis patients.
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This is an epistatic compensatory process explaining why mutations that are deleterious in some species are tolerated in phylogenetically related lineages, rendering evident that those mutations are, by all means, only deleterious in the species-specific context.
On the other hand there is no indication that IT is deleterious in-patient with food allergy related to pollen sensitizations.
Even if the presence of such proteins may be deleterious in many natural [28] or over-expressing [29] conditions some recent studies show that yeast prions may be involved in a fast adaptation mechanism in stress conditions [30].
It seems beneficial for patients with fluid overload, but might be deleterious in the absence of hemodynamic failure.
The development of hyperchloremic acidosis associated with normal saline (NS) administration may be deleterious in septic shock.
Acute respiratory failure (ARF) in this specific population can be challenging for the intensivist, as OPE requires ultrafiltration which could be deleterious in other causes.
A 2nd concern in the intensive care unit is acute adrenal suppression secondary to bolus etomidate therapy because it may be deleterious in patients with septic shock.
The polygenic burden was driven both by the number of variants per individual, and over-representation of variants likely to be deleterious in the SUDEP cohort.
Since it has been demonstrated that fluid overload can be deleterious in patients with acute respiratory distress syndrome [1] and severe sepsis [2], it is of paramount importance to avoid excessive fluid administration in such cases.
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