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According to Knudson's "two hit hypothesis", both copies of a tumor suppressor gene should be deleted by a mutation or allelic loss to reduce protein dosage [ 41].
For example, a tumor-suppressor gene might be deleted by a small focal aberration in one sample, while in another sample the same gene is deleted by a whole chromosome loss.
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I have a phrase which aptly describes this phenomenon, but it would most likely be deleted by an editor or certainly challenge my claim to be a lady.
Utilizing mice in which the LepR is flanked by loxP sites and can be deleted by an AAV Cre, HFD for 20 weeks induced increased SBP at baseline, whereas AAV Cre administration into the DMH (hence deleting the LepR in only the DMH regions) decreased SBP.
For deletion of putative target genes, the open reading frame was deleted by a PCR stitching method as described in detail in Kwon et al. (2012).
At the top, the snow falls so unwaveringly that any visual markers are deleted by a blizzard of white.
The spokesman, Barry Schnitt, said that when a photograph was deleted by a user, it was removed from all of the company's servers within 90 days.
In a public letter to the Federal Trade Commission in January, Adobe condemned the practice of restoring cookies after they had been deleted by a user.
4.17pm: It has emerged that a key June 2008 email from then News of the World editor Colin Myler to James Murdoch was deleted by a member of News International's IT department in January 2011 and not recovered until the end of last year.
"The evidence strongly indicates that Ms White believes her breasts were twice clasped by a police officer, that she took photographs of the police officer she suspected of indecently assaulting her; the photographs were deleted by a police officer before the phone was returned to Ms White," Bradd said.
John Romano of the specialist news site The Digital Beyond told how the family of one soldier killed in Iraq were refused access to his emails by Yahoo, how one author's entire online body of work was deleted by a family who did not like it, and how one man struggled to wrest control of his dead wife's Facebook page from abusive commenters.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com