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The discovery that aging can be delayed in mice is just the kind of experiment one might suppose would be supported by the National Institutes of Health, the government agency that spends $30 billion a year on financing biomedical research.
Chondrocyte hypertrophy could be delayed in mice with a PTH1R mutation that specifically interrupted the PLC/PKC pathway but did not affect cAMP/PKA activation [ 43].
Does the reduction of oxidative stress have any physiological relevance with regards to the benefits of CR? Hearing loss is a hallmark of aging, and has been shown to be delayed in mice by CR.
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The solid tumors appeared on day 5 and quickly expanded over the next 2 days in the control mice, while the growth of tumors was delayed in mice treated with EGF-SEA (Figure 1B).
The resolution of inflammation was delayed in mice challenged with the first isolate and the message for IFN-γ and TNF-α in the spleen was lower within the first few hours post-infection.
The comparative analysis of leukocyte recruitment to the peritoneal mouse cavity of mice infected with 124A or 140A showed that even though resolution of inflammation was delayed in mice infected with 124A, immunocompetent mice recognized both isolates similarly, invoking an acute neutrophilia, as previously described [35], [46], [47].
Furthermore, gastric emptying was delayed in mice that received liquid EN with pectin than in those that did not.
Involution is delayed in mice overexpressing human IGF-I or des(1 3 IGF-I due to reduced alveolar apoptosis [ 28, 29].
However, Pagel and colleagues found that earlier stages of bone repair are delayed in mice lacking PAR-1 [ 55].
The appearance of anti-α-fodrin and anti-M3RP antibodies was delayed in mice immunized with α-fodrin.
This is delayed in mouse models with increased maximum life span because of growth hormone and/or insulin-like growth factor-1 (IGF-1) deficiency.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com