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Molecular subtypes can be defined by microarray testing and this classification approximated using IHC results of ER, PgR, HER2 and other proliferation biomarkers.
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At least four genetically distinct breast cancer subtypes have been defined by microarray profiling [ 89], and at least two types of stem cells have been identified within these subtypes - basal progenitors and luminal progenitors [ 90].
So, although the experimental-variable subsets of GEO microarrays are defined by microarray developers, and the experimental variables are subjected to the hypothesis that the researchers wanted to investigate, these micrroarray data can be reused for investigations around the world even when their hypotheses are completely different from the originals.
The implicated chromosomal regions were defined by microarray analysis, the patient had a trisomy 1q41-qter of 30.3 Mb in extension comprising about 240 protein coding genes and a monosomy 3p26.3-pter 3p26.3-pterncluding ofly the genes CNTN6 (MIM 607220) and CHL1.7MbM 607416), whincludingbeen implicated in dendrite develonlynthe
The new data matrix need not be defined by a microarray, it could easily be the result of RT-PCR or any other expression assay, imported into R as a tab-delimited text file.
"I want to be defined by consistency.
Don't be defined by a label.
The next level of clustering was defined by the microarray platform used for the studies.
In order to give biological annotation to REGs, we decided to utilize microarray data to predict the biological responses of cis-elements that are defined by the corresponding microarray experiments.
The chromosomal regions involved were defined by high-density microarray techniques and their effects in the phenotype regarding the definition of the syndromes are discussed.
Our RUD values were based on microarray probes targeting cUTR and aUTRs that are defined by proximal and distal poly(A) sites.
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