Rather, systems this size seem to obey a unique set of rules that cannot be deduced from studying their individual components.
Data concerning the safety and possible efficacy of rFVIIa in patients with polytrauma and TBI will need to be deduced from studies in hemodynamically stable patients with TBI.
Comparisons between the genomes of apple and pear, which belong to the subfamily Maloideae, indicate a very high level of synteny, and no major chromosomal rearrangements can be deduced from studies of common markers mapped in these genera [ 16, 17].
One possible mechanistic explanation for these paradoxical effects can be deduced from studies showing that POPs such as dioxin lead to a decrease in liver gluconeogenesis in several cellular and animal models mainly through the repression of phosphenolpyruvate carboxykinase (Viluksela et al. 1999).
Most of its cellular mode of action has been deduced from studies performed on renal cell lines or purified membranes.
- How the enzyme component of CDT is translocated through the pore, is deduced from studies with iota toxin and C2 toxin.
The role of Sema3A in maturation and/or differentiation of the distal lung epithelium during development was deduced from studies on Sema3A-null mice.
For intraperitoneal (ip) injections, drugs were dissolved in 0.9% saline; the doses used, that is, 0.1 mg/kg SCH-23390 and 5 mg/kg SKF-38393, were deduced from studies on mechanisms of emotional learning in rats (Greba and Kokkinidis 2000; O'Tuathaigh and Moran 2002).
The applied dose of m-CPP was within the range shown to exert, after intrastriatal infusion, similar effects as intrastriatal SKF-38393 on oral activity responses in rats (Plech et al. 1995); the doses of SCH-23390 and SKF-38393 were deduced from studies on mechanisms of working memory and attentional performance in the rat prefrontal cortex (Seamans et al. 1998; Granon et al. 2000).
It can be deduced from this study and our sub-study that infants who miss two to three consecutive doses can still obtain the nevirapine concentration of 100 ng/ml, therefore they would need to receive at least twice weekly doses given a maximum of 72 hours apart.
