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The number of peripheral blood DCs appears to be decreased in several types of cancer, including pancreatic cancer [ 15- 20, 31, 32].
Neurotensin has been found to be decreased in several brain areas of human AD brains [24 26], and neurotensin analogues rescue memory deficits [27].
BiP is a general marker of ER stress that is applicable to skeletal muscle cells (30, 31), whereas Bcl-2 has a protective role in skeletal muscle and has been shown to be decreased in several myopathies (32, 33).
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Currently, death rates seem to be decreasing in several of these countries in crisis, but causes of mortality behave differently [ 4– 6].
It has been reported that the antinociceptive potency of morphine is decreased in several rodent models of hyperglycemia, including streptozotocin-induced diabetes, an animal models of type I diabetes.
Most of circulating IGF-I is derived from the liver and circulating IGF-I levels are decreased in several pathological conditions, such as liver cirrhosis, uncontrolled diabetes, renal failure, and malnutrition.
Some studies have previously shown that miR-143 could play a role in tumorigenesis since its expression is decreased in several cancers [19].
Apoptosis values by cellular population (Table 2) were decreased in several cellular subsets in systemic sclerodermas.
Histone phosphorylation is increased and histone acetylation is decreased in several regulatory and gene coding regions.
On the transcriptional level HEPACAM1 expression is decreased in several human cancer types including breast cancer but protein expression was not analyzed so far [ 10].
However, miR-15a and miR16-1 are not invariably included in 13q deletions, and although their expression is decreased in several CLL patients, a clear correlation with the number of deleted 13q alleles has not been found [ 7].
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