It is critically required to develop a solution to recycle and reuse these potential resources.
While these mechanisms are critically required to help cells survive under dynamic physiological circumstances, they also pose an impediment to the effective treatment of cancer.
On the other hand, this ant colony-based model could automatically determine the number of clusters that was critically required to be input in other clustering algorithms such as k-means, fuzzy c-means, and e-m clustering.
Our results suggest that enhanced analytical sensitivity is critically required to correctly identify patients responding to EGFR inhibition.
BAG3 induction is critically required to mitigate ST80/Bortezomib-triggered proteotoxicity by clearing protein aggregates via selective autophagy.
Thus, studies geared at providing novel insight into the molecular mechanisms leading to age-related immune dysfunction are critically required to address the need for novel therapeutic interventions for a growing elderly population.
Interestingly, recent work on the effect of Lkb1 inactivation in mouse hematopoietic stem cells showed that, while LKB1 was critically required to regulate energy metabolism and maintain cell survival, the effects were again largely independent of AMPK and TORC1 signaling [ 40- 42].
In contrast to MCL-1 phosphorylation, which we demonstrate to be critically required for Taxol-induced apoptosis, the Taxol-stimulated phosphorylation of BCL-2 represents an antiapoptotic event during Taxol-mediated apoptosis.
Using this particular method, the sart3 gene was found to be critically required for thymus development through regulation of the U6 small nuclear ribonucleoprotein [ 35].
In this regard, the activation of Notch was found to be critically required not only for adult myogenesis, but also for maintenance of neural stem cells and a proper control of adult neurogenesis [ 13, 42].
