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Identification of key issues associated with scale-up for these specific pilot plant vessels was believed to be critical to efficient process development, clinical material production, and expected process transfer to a manufacturing facility.
The close and precise alignment of DHPRs and RYRs in a structure called the "couplon" is thought to be critical to efficient CICR [3], [4].
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Both fast and accurate block-matching algorithms are critical to efficient compression of video frames using motion estimation and compensation.
Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is critical to efficient drug development.
In hierarchically managed network-on-chip (NoC) based manycore systems with over one thousand processor cores, resource management is critical to efficient operation of the whole system.
The role of enhancing and positioning vortices is critical to efficient locomotion.
As mRNA stability around the start codon is critical to efficient translation, the RBS spacer might be another factor to consider, other than the presence of an RBS.
Our results describe a molecular pathway promoting cytoskeletal reorganization that is activated downstream of a CD44-induced, integrin-dependent event and that is critical to efficient breast cancer cell adhesion to hBMECs.
Meanwhile, a profound understanding of the mechanism of osteochondral repair could be critical to develop efficient and effective therapeutic strategies to treat osteochondral defects.
This protecting group combination on histidine was found to be critical to ensure efficient access to the requisite activated building block.
This study also provided evidence that the formulation pH is a very important factor that may be critical to design efficient carriers for BMP-2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com