Heparin and heparan sulfate mediate a number of biological interactions, such as cell adhesion, cell proliferation, or cell surface binding of lipase and other proteins that are critical in developmental processes, blood coagulation, angiogenesis, viral invasion, and tumor metastasis.
Dosage regulation could be critical in a developmental window but be less stringent in preimplantation development and at the end of the developmental program.
This indicates that ADAM17 and EGF pathway substrates shown to be critical in other developmental systems are present on the non-TEC populations in the thymus.
Such a differential alteration of a key developmental gene may be critical in defining the phenotypes of these tumors and explain the behavior and outcome from these disparate forms of this disease.
Developmental studies of Monoplacophora will be critical in providing insights into this question.
Instead, like most developmental processes, a strict temporal and spatial control of their expression could be critical in RA pathogenesis.
In mammals, imprinted genes are critical in numerous developmental and physiological processes.
While it is true that expertise is critical in project implementation, developmental project needs female inspiration, passion and commitment to change the status quo than a gender biased expertise based project staffing.
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses.
In addition, RBD mutations have been used to demonstrate that input of RAS binding to the single Drosophila type I PI3K is critical in insulin-pathway-controlled developmental growth (Orme et al., 2006) and that RAS binding is required for PI3K activation by chemoattractants in Dictyostelium (Funamoto et al., 2002).
