Sentence examples for be critical in binding from inspiring English sources

Remarkably this mAb uses the IGHV1-69 geneline gene and conserves the hydrophobic residues at the tip of the HCDR2 loop that we show in this study to be critical in binding the conserved hydrophobic pocket of HA.

Five out of six residues, Asn21, Arg24, Arg32, His90 and Ser93, which are determined to be critical in binding, are also predicted to be in the interface.

In fact, Pro72 is part of a PXXP motif known to be critical in binding of a p53-specific inhibitory protein, iASPP (inhibitory member of the apoptosis- stimulating protein phosphatase family) (Bergamaschi et al. 2006).

Moisture content is a primary quality attribute of pelleted biomass materials because it is critical in binding, storage, combustion, and the pricing of pelleted biomass.

The proximal promoter has been defined as the region immediately surrounding the transcriptional start site, which is critical in binding polymerase complexes necessary for gene transcription [11], [12].

The chain length of the substitution at the 9-position was found to be critical in modulating the binding affinities.

In particular, the two elements YRG and RAYD within the AP2/ERF domain had been reported to be critical in activating DNA binding to modulate the expression of target genes in Arabidopsis[ 3, 36].

(i-ii) residues shown to be critical in co-crystal structures for substrate binding in mouse ERK2 are colored in blue.

Semisynthetic phospho- and unphosphorylated PTEN containing four mutations K13A, R14A, R15A, and R161A ('N-mutant') was constructed to test the possibility that these basic residues in the N-terminus, co-localized in the crystal structure and implicated in phospholipid binding, might be critical in stabilizing the closed 4p-PTEN conformation.

Moreover, several residues known to be critical in the caspase-3 catalytic centre and binding pocket, as well as the active-site pentapeptide motif Q172ACRG176 were present in the deduced Lyccasp3.

LANA R9 is critical in nucleosome binding as mutation of this residue eliminates LANA's chromatin association.