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In this population, autocrine IL-6 could be sufficient to trigger cell cycling, whereas the BM environment could be critical for triggering survival by producing other survival factors.
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This event is critical for triggering ESCs to differentiate.
Targeting TNF α may also be desirable because it is critical for triggering JNK-mediated apoptosis.
Inflammasomes sense infection and cellular damage and are critical for triggering inflammation through IL-1β production.
Calcium binding at Ca2 is critical for triggering the movement of the active site cysteine into a catalytically competent position.
PROBLEM: Inflammasomes sense infection and cellular damage, and are critical for triggering inflammation through IL-1β production.
Together, these data apply that the amount of Mss4 protein in cells is critical for triggering cells into programmed cell death.
However, pifithrin-μ also modulates other proteins (e.g. heat shock proteins) and genetic evidence is yet lacking that p53 is critical for triggering MOMP in the setting of perinatal brain injury.
Upon cleavage, the protein protein interaction between cleaved GP1 and NPC1 is critical for triggering the membrane fusion machinery, although it remains to be determined if other factors are involved.
Consistent with these data, a number of studies using more contemporary experimental manipulations have confirmed that a number of sites in both hypothalamus and brain stem are critical for triggering counter-regulatory responses.
Mitochondrial perturbation occurs either after TG-induced intracellular Ca2+ release from the ER or upon the activation of caspase-8 and is critical for triggering the intrinsic caspase-9-dependent apoptotic pathway.
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