Sentence examples for be critical for certain from inspiring English sources

The ability of CRISPR to generate genetic loss of function mutations not only increases the magnitude of any effect over currently employed RNAi techniques, but allows analysis over longer periods of time which can be critical for certain phenotypes.

The timing of measurement of gene expression changes appears to be critical for certain groups of genes.

Thus, increased peripheral NGF levels lead to increased production and release of BDNF from the central synapses of nociceptors in the spinal cord, and this may be critical for certain central sensitization events, especially those involving N-methyl d-aspartate (NMDA) receptors (Kerr et al., 1999).

Since the hippocampal network is critical for certain types of memory[1], [2], it is very important to address whether and how LTP and LTD are induced simultaneously in vivo, a condition essential to address whether and how the state of the network itself affects the induction.

Given that most of the aforementioned signaling pathways are critical for certain developmental processes and patterning events, one might have predicted from the in vitro studies that secreted sulfatase-deficient mice would have exhibited profound developmental defects in a multitude of organ systems.

SGZ NSCs produce excitatory neurons that integrate into the dentate gyrus and are critical for certain types of hippocampus-dependent learning and memory [ 1, 3].

A better understanding of the biological mechanisms behind these antibiotic associated effects on growth is critical for certain populations, such as children under 2 years old (as reversal of stunting beyond this age is challenging 2), and HIV infected, HIV exposed, and acutely malnourished children in whom antibiotics continue to be a standard component of care.

Aldehyde dehydrogenases (ALDHs; EC1.2.1.3), consisting of 19 putatively functional genes with distinct chromosomal locations in human, represent a group of enzymes that are critical for certain life processes and detoxification via the NAD(P +-dependent oxidation of a wide range of endogenous and exogenous aldehyde substrates to their corresP +-dependentxylic acids.

TNF- α-induced necroptosis of HT-22 cells is largely independent of both ROS accumulation and calcium influx although these events have been shown to be critical for necroptosis in certain cell lines.

Although downstream mechanisms mediating execution of necroptosis remain to be elucidated, reactive oxygen species (ROS) accumulation [ 13, 18] and calcium influx [ 19] have been shown to be critical for necroptosis in certain cell lines.

If the PCR fails, increasing the MgCl2 concentration (2 mM) and/or adding Enhancer should be tried as these proved to be critical for successful PCR for certain taxa.