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The affinity of IgE antibodies to the allergen has been shown to be critical for cellular activation.
E6 has several functions, but its role in p53 degradation is thought to be critical for cellular transformation.
Furthermore, reactive oxygen species (ROS -mediated cellulaROS -mediatedhas shown to be cellular for cellular growth, angiogenic, and other oncogenic pathwaysignalling
Although migration was shown to be metalloproteinase mediated, these cells actually showed a downregulation or no change in the level of key metalloproteinases, indicating that changes in cellular adhesion properties can be critical for cellular mobility.
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Maintaining genome integrity and transmission of intact genomes is critical for cellular, organismal, and species survival.
Polo-like kinase 1 (plays plays key roles in regulating various mitotic processes that are critical for cellular proliferation.
Thioredoxin reductase (TrxR) is critical for cellular redox regulation and is involved in tumor proliferation, apoptosis and metastasis.
It encodes 13 polypeptides all of them components of the OXPHOS system, and thus, the integrity of the mitochondrial DNA (mtDNA) is critical for cellular energy supply.
Their presence is critical for cellular fitness because they minimize the effective cell volume, allowing faster adaptation to environmental changes that require de novo synthesis of envelope proteins.
Mutant studies in Arabidopsis revealed that cytosolic APXs (APX1 and APX2) are critical for cellular H2O2 homeostasis and play an important role in growth, development and oxidative protection of chloroplasts under various abiotic stresses (Pnueli et al. 2003; Davletova et al. 2005; Koussevitzky et al. 2008; Zhang et al. 2013).
Specifically, RB status was critical for cellular response to damage and senescence, irrespective of p53 function.
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