Sentence examples for be critical for activity from inspiring English sources

The substituted benzene ring of the isatin scaffold is thought to be critical for activity where the slight displacement of its fused benzene ring away from hydrophobic pharmacophore center (Figure 4b) or displacement of the isatin nitrogen away from the hydrogen bond donor pharmacophore center (Figure 4c) can partially explain their lack of activity.

The cysteine, histidine and glutamine residues forming the catalytic triad in CifEc were shown to be critical for activity [10].

Phosphorylation of Rubisco subunits has been demonstrated to be critical for activity, association and assembly of the Rubisco multicomponent complex [ 39, 40].

1,2,3,4,6-Pentakis[-O- 3,4,5-trihydroxybenzoyl)]-α,β-D-glucopyranose (PGG) 1,2,3,4,6-Pentakis[-O- 3,4,5-trihydroxybenzoylities, where the free OH groups in PGG seem to be critical for activities.

Thus, as predicted by conservation, the active site helix arginine is critical for activity across the superfamily.

We also demonstrated that the relative stereochemistry of the amino acid at the 6-position is critical for activity, and could play an important role in potency as well as in selectivity for the melanocortin receptors.

To determine the location of elements within the ALF promoter that are critical for activity in oocytes, several additional series of mutation/deletion constructs were made.

Additional experiments using a series of site-specific promoter mutants identified two cis-elements within the 63 base pair minimal promoter that were critical for activity.

In contrast to Ca6, however, Ca1 is critical for activity because Ca1 site substitutions decrease kcat/ KM by >2350-fold.

Secondly, the results of the present study show that several residues which appear to be universally conserved among α-kinases are critical for activity.

This is consistent with the conclusions from the previous mutational analysis that only a limited number of residues are critical for activity [ 7].