They can excise from the donor site (they are known as cut-and-paste transposons, and the transposition is described as conservative) although this is not always the case, since several Class II elements are replicative (i.e. their transposition is coupled with replication).
As a result of the yeast studies, it has been proposed that early DNA replication may be coupled with CENP-A incorporation (Koren et al., 2010).
The core idea of GREACE is to introduce genetic perturbations into genome replication machinery, so that in vivo continuous mutagenesis can be coupled with simultaneous phenotypes selection.
Although these results do not exclude the possibility of replication-independent ICL repair, most of the repair events we observed were coupled with DNA replication.
Recent studies provide clues into how RNAi and heterochromatin formation are coupled with DNA replication, thus providing mechanistic insight into how H3K9 methylation is inherited.
The repair of interstrand DNA crosslinks induced by chemotherapy drugs is coupled with DNA replication and controlled by FA proteins.
In S/G2, the repair of ICLs is coupled with DNA replication and depends on Fanconi anaemia proteins and homologous recombination (Fig. 2).
According to this hypothesis, mtDNA replication is coupled with mitochondrial activity and is dependent on mitochondrial fitness: [ 88] showed that impaired replication of mutant genomes during Drosophila oogenesis prevents the transmission of mutant mtDNAs which are purged from the mitochondrial population.
We use this model to elucidate the reciprocal roles of the known factors affecting DnaA activity in E. coli, namely that DnaA expression is dependent on transcriptional autoregulation, and that its ATP-ase activity is coupled with the activity of the advancing replication forks (RIDA).
Conceptually, hematopoiesis has been rationalized as a multi-step process where cell replication and differentiation are coupled with cells moving through successive stages – compartments - of maturation in a series of steps from HSC all the way down to mature blood cells.
