Large increases in gene number have been coupled to increases in organismal complexity and radiative divergence at several points in the history of metazoans including during the chordate/vertebrate transition and during the teleost fish divergence [ 1, 4, 5].
Naturally, this is coupled to increasing demand for individuals with the necessary skills and training to do these tasks--individuals who can understand the basic science and recognize its implications and potential, but who are also familiar with how we can translate these findings into new or improved treatment and prevention strategies.
It is known that DC activation is coupled to increased cell migration to lymphoid organs [41].
A low frequency of stromal AR was coupled to increased Gleason score, metastasis, poor response to castration therapy and an unfavorable outcome.
The enhanced neurodegeneration was coupled to increased caspase 3 activation, which indicates an onset of apoptosis, seemingly independent of tau.
Positive associations then reflect relations where increasing miRNA expression is coupled to increasing protein levels (and decreasing miRNA expression with decreasing protein levels).
In contrast to the concentration range of 0.1 and 0.5 % final acetoin, higher amounts of acetoin (1.0 and 1.5 %) are coupled to increased cell lysis (data not shown).
Even so, there are precedents for endocannabinoid CB1 receptors being coupled to increased NO synthesis (Poblete et al., 2005; Romano & Lograno, 2006).
Activation of mitogen/extracellular-signal-regulated kinase kinase 5/extracellular signal-regulated kinase-5 (MEK5/ERK5) growth signalling is coupled to increased cell proliferation in prostate cancer (PCa).
These fibrotic bursts may be induced by local injuries of the heart muscle, which result initially in local increase of fibroblast proliferation and are coupled to increased apoptosis as evidenced by elevated cleaved caspase 3-staining and abundant cardiomyocyte necrosis.
