Sentence examples for be coupled to expression from inspiring English sources
Gene expression is modulated by trans-factors and upstream and downstream non-coding sequences and therefore the molecular evolution of genic sequences need not be coupled to expression evolution.
In some organisms, swarming is controlled by quorum sensing, and in others, swarming has been shown to be coupled to increased expression of important virulence factors.
Although 200 Cbt targets seemed to present both modifications, these may be coupled to the differential expression pattern of several genes in the wing disk.
The reduction in miR-21 expression could be coupled to a decrease in SOX2 expression, loss of tumor-initiating ability of the cells and induction of oligodendrocyte differentiation [ 33].
The mutation pattern we observed in AR-B is indicative of a neofunctionalization event at the functional level, but it is likely that this may also be coupled to differences at the expression level.
To address this issue, exogenous MECP2 expression could be coupled to specific knockdown of the endogenous MeCP2 to preserve total expression levels in heterozygous patient cells [38].
It has been shown that alternative splicing can be coupled to NMD to regulate the expression of other transcripts from a gene [ 25].
Indeed, such physiological changes are expected to be coupled to massive changes in gene expressions, which can explain the hotspot.
Furthermore, increased H1.5 expression may be coupled to the proliferative capacity of growth-stimulated T cells.
Results This study describes the generation of the first Drosophila spliceosensor model – transgenic flies in which the expression of human disease-linked splicing variants expressed from minigenes is coupled to the expression of a reporter – and their use in the in vivo identification of splicing modulators for DM1.
