The LuxI/LuxR QS system is coupled to cellular motility via the transcriptional repressor gene cI, which is induced by AHL via the promoter PluxI and inhibits the expression of cheZ, one of the essential genes in bacteria motility.
Cellular GSH concentration is dependent on the activity of gamma-glutamyl cysteinyl ligase (GCL) and cysteine availability [8]; expression of the rate limiting GCL enzyme is coupled to cellular redox state through the Nrf-2-KEAP1 system, providing a mechanism for cellular adaptation to oxidative stress through de novo GSH biosynthesis [8].
Next we asked whether DNA replication licensing is coupled to cellular differentiation in breast cancer.
For example, it has been shown that expression of era is coupled to cellular growth (fast growth > Era) in E. coli [ 23].
Additionally, CBS has been shown to be abundant in actively proliferating cells where its activity is coupled to cellular metabolic demands through allosteric activation by AdoMET, which also appears to regulate CBS-mediated H2S production in neurons.
Using mutant analysis, laser ablation, optogenetics, and Ca2+ imaging, we observed that following C. elegans male copulation, the duration of post-coital lethargy is coupled to cellular events involved in ejaculation.
These transcriptional changes could imply that scleroglucan synthesis might be coupled to the cellular ion homeostasis machinery.
However, our knowledge of prions in higher organisms is limited to a handful of examples associated to serious illnesses, thereby the need for strategies that can point out new putative candidates that might be coupled to other cellular functions.
Once RV disease has been characterized using clinical symptoms, exercise and/or mortality (Table 1), the disease state can be coupled to hemodynamic and cellular adaptation (Table 2).> -wrap-foot> Numbers are percentages increase/decrease versus controls.
