Sentence examples for be core mediators of from inspiring English sources

Ideally these targets should be core mediators of important processes and not downstream components of the response [21].

IL-18 is a core mediator of angiogenesis and inflammation in rheumatoid arthritis pannus formation [ 28].

These proteins can be inhibitors or mediators of inflammatory processes.

MED1 is part of the core mediator module while MED12 is part of the mediator kinase module [ 74, 75].

Inflammasome-regulated cytokines are critical mediators of acute lung injury.

Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation.

Neuroendocrine functioning may be a mediator of such outcomes.

To determine whether this extends to subunits of the core mediator, binding of the tail subunit MED5/24 was examined.

A core IRIF component is the mediator of the DNA-damage checkpoint protein 1 (MDC1; Goldberg et al, 2003; Lou et al, 2003; Stewart et al, 2003; Stucki et al, 2005).

Rpn4, in addition to being a major mediator of core Rpn4-proteosome feedback circuit also appears to be a major mediator in a stress response network (Xie, 2010).

These contradictory observations suggest that the previous understanding of the modular organization of the core Mediator is most likely confounded, posing a significant impediment to understanding the detailed architecture and molecular mechanisms of Mediator.