A computational analysis study is done to find which low-risk strain is showing most similarity with the high risk there by predicting that this low-risk strain can be converted to high-risk if a mutation occurs in future.
Two separate groups have previously reported that an IgG could be converted to a monomeric IgG by introducing mutations at residues 351, 366, 368, 395, 405, 407, 409 (Ying et al., 2012), or by introducing two Asn-linked glycans at positions 364 and 407 (Ishino et al., 2013).
8a The minimal activation of Parkin by UbC46 is most likely attributable to the Ala46Cys mutation (which can be converted to the native Ala).
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However, when a bottom strand T/G is converted to T/A, most mutations are on the G of GpA.
All point mutations were converted to binary data (0 = no mutation, 1 = somatic mutation) for each sample, and a matrix with sample names in rows and loci in columns was generated.
Surprisingly, the originally stable ben1-1 mutation was converted to a partial loss-of-function mutation in the triple mutant background.
Thus, when a top strand T paired with a bottom strand G is converted to T/A, most of the mutations are on C, ∼80% of which involve the C of TpC with almost no specificity for the 3′ base (top panel, Figure 3 figure supplement 5).
The PMA1 URA3 variant was created from the pma1Δ::KanMX4/PMA1 strain; the ura3Δ0 mutation was converted to URA3 via PCR amplification of URA3 from pRS306 and transformation.
Maynard Smith illustrated the two-fold cost of males in sexual reproduction using an example in which a sexual mother was converted to a clonal mother by mutation [ 3].
