Studies on the role of hCdc14B in cell cycle regulation have been controversial, depending on the experimental systems used, e.g. depletion by RNAi, overexpression or gene knockout in cultured cell lines.
Various studies have also reported that P2Y2R is most consistently expressed by tumor cells, however the role of P2Y2R on the tumor growth is controversial depending on tumor types [ 9– 15].
Although the prognostic role of P-cadherin expression on clinicopathological features is controversial depending on the cancer type, our results demonstrate that P-cadherin expression reflects tumor aggressiveness and disease recurrence in ICC and pancreatic cancer.
Studies on the effects of sociodemographic variables in subjects without brain injury show a strong educational effect on performance in the TT, but the effect of aging is controversial, depending on the version of the test employed, the scoring system used, and the age range studied, with decline being most evident beyond 65 years of age [ 21, 27– 30].
Businesses reply, with equal reason, that the EPA--with a staff of 17,000 bureaucrats devoted to proposing, researching and enforcing new regulations--hardly has an incentive to downplay the benefits of new red tape.Judging the costs and benefits of a particular rule will always be controversial, depending as it often does on putting a money value on lives saved.
ERK has also been shown to be phosphorylated upon TLR4 signaling, but its involvement in TLR4 maturation is still controversial, depending on the culture system [34], [36], [37].
As an immunostimulant, the ability of chitosan in inducing mixed Th1/Th2 immune response is still controversial depending on the administration routes (Shibata et al., 2001; Porporatto et al., 2005; Oliveira et al., 2012).
Although functions of some of these modulated genes are somehow controversial, depending on cellular context (e.g. ARHGDIB can both inhibit and positively regulate Rac1), these observations collectively suggest that regulation of Rac1 and Rho/ROCK pathways may be impaired, possibly resulting in reduced motility.
The role of statins in carcinogenesis is still controversial depending on the type of tumor.
Meta-analyses can be challenging and controversial depending on assumptions, particularly for studies on occupational and environmental exposures that frequently are not easy to quantify.
