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Grade 3 peripheral sensory neuropathy remains an important problem that might be controlled by dose reductions and delays before the symptoms worsen.
Treatment was discontinued when the patient had recurrence of disease or adverse reactions unable to be controlled by dose modification or temporary withdrawal of S-1.
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However, mice in which JAK2V617F expression was induced by Mx1-Cre [where Cre expression is transient and the levels of Cre expression can be controlled by dose-dependent activation of the Mx1 promoter with polyinosine-polycytosine (pIpC)] generally retained higher JAK2V617F transgene copy number than in the Vav-Cre model and displayed increased erythrocytosis as well as thrombocytosis.
It was demonstrated that the phases formed are controlled by dose rate and chemical composition of steels.
The synthesis of the samples obtained, pre-irradiated in air or argon atmosphere, was controlled by dose and concentration of inhibitor, provided as Mohr's salt, in the ranges from 2.5 to 10 Mrad and from 0.005 to 0.500 wt%, respectively.
The tribological properties of the carbon-implanted TiN films can be controlled by carbon dose and ion energy: wear rate and frictional behavior of the TiN coating can be reduced.
In mouse it has been shown that the rate of recombination can be controlled by the dose of the ligand administered [24].
Growth of microorganisms, parasites, and insects on certain foods (such as meat, poultry, spices, fruits, and vegetables) can be controlled by low-dose irradiation, which has been approved for specific uses in a number of countries, such as Japan, France, Italy, Mexico, and the United States.
For that reason and considering the high cost, TNF-α therapy in PMR and GCA seems justified solely when these diseases can only be controlled by GC doses that are untenable due to serious adverse effects and comorbidities induced or worsened by steroids.
The core shell ratio can be controlled by varying the dose of CuCl2, VC, or PAM.
Moreover, the morphology of metallic nanoparticles can be controlled by manipulating the radiation dose and dose rate (Abedini et al. 2013).
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