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In this regard, whether Hotair accumulation results from aberrant upstream signaling is unknown, nor is whether and how miR-568 or NFAT5 may be controlled by alternative signaling, for example, the well-defined pathways involved in mammary malignancy [ 14].
Finally, our finding that the chicken Muc13 is distributed between multiple exons raises the interesting possibility that the length of the PTS domain could be controlled by alternative splicing.
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The binding affinities of Nrxs and NLs are controlled by alternative splicing of both molecules (Comoletti et al., 2006; Boucard et al., 2005; Chih et al., 2006).
FCA and FY interact and FCA transcript levels are controlled by alternative splicing which is conserved in grasses [112], [113].
The neuroligins represent a similar class of proteins to neurexins and the binding of the two types of molecule to each other is controlled by alternative splicing.
Expression of human Interleukin-5 receptor alpha (hIL-5Rα) is controlled by alternative splicing, which generates two different transcripts encoding a membrane-anchored and a soluble form of the receptor, respectively.
Taken together, these results suggest that the ability of SKIP to stimulate outward movement of lysosomes is controlled by alternative splicing and hence the ratio of the two SKIP splice variants could provide a mechanism to fine-tune the distribution of lysosomes in different cell types.
This data together with findings that induction of IL-10 expression in alternatively activated macrophages is TLR2-dependent suggest that CD40 signaling may likely be controlled by anti-inflammatory output of alternative activation of bovine macrophages induced by S. aureus infection.
TE activities might not always be controlled by DNA methylation, and instead may be controlled in alternative manner(s) such as by gap repair [ 30, 31] or unknown host function(s) to prevent harmful behaviors by TEs.
Incubation of temperature-sensitive strains, such as dnaC and dnaA, under non-permissive conditions is expected to induce expression of heat shock genes which are controlled by an alternative sigma factor, RpoH [21].
We know that cell fate during mitotic arrest is controlled by two alternative pathways, one that promotes slippage out of mitosis and cellular survival from mitotic stress, the other that promotes cell death [13].
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