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While proto-oncoproteins like cyclin D1 and pro-survival factors like survivin are encoded by mRNAs with long and highly structured UTRs that can be controlled at multiple levels.
Cytokine release can be controlled at multiple levels, including the central nervous system (CNS).
TLR4 signaling can be controlled at multiple levels by many regulators [ 4].
miR-98 expression can be controlled at multiple levels, including synthesis of the primary transcript, Drosha processing to the precursor, and Dicer processing to the mature form [ 35].
In eukaryotes, gene transcription is mainly performed by RNA polymerase (Pol) II and can be controlled at multiple stages including pre-initiation, initiation, elongation, and termination (Shilatifard et al., 2003; Sims et al., 2004).
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The assembly of antigen receptors is controlled at multiple levels, including epigenetic marking, nuclear location, and chromatin topology.
Such fidelity is controlled at multiple steps and can be compromised in nature and in the laboratory to rewire protein synthesis with natural and synthetic amino acids.
In lymphocytes as with all other eukaryotic cell types, the program for cell division is controlled at multiple regulatory points throughout the cell cycle [13], [14].
RNA translation and mRNA degradation are dependent on specific cis-acting sequences and trans-acting factors [1], [2], and expression of the trans-acting regulatory proteins is controlled at multiple levels.
The efficiency of mRNA translation is controlled at multiple levels by different mechanisms.
Changes in the expression of coding genes are controlled at multiple levels, from transcription to RNA processing and translation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com