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The lack of a single engineering strategy that improves protein secretion across the board implies that there are several possible bottlenecks in the secretory pathway, and different proteins may be constrained in different ways.
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As clearly illustrated in Figure 3, some parameters are constrained in different value ranges depending on which objective function is used to assess the model behavior.
Thus, different types of proteins are constrained in different ways by very hot environments.
A series of models was run in which the change in slope at each knot was constrained in different ways (e.g., a threshold model in which the slope of the first piece of the linear model was constrained to be 0).
Our sampling space is huge (23 parameters, with most of them sampled over 4 orders of magnitude, Additional file 2, Table S1) and we looked for parameters that would be constrained in the different response types.
Unlike repeats which disrupt the reading frame, and have a strong effect on replication and transcription stability[ 31], the tri-nucleotide repeats might be constrained in a different way.
Note that (theta in mathcal {L}) has N disjunct sets of n atomic propositions, and each set is used to build formulas whose probability was constrained in ϕ for a different probability measure.
Finally, tropomyosin coils are constrained in these insects but at different levels in Drosophila and mosquitoes.
We consider that sensor nodes have different communication and storage powers and all the nodes are constrained in energy.
I'm afraid I'm constrained in explaining that.
"We're constrained in the amount of land," Mr. Jacoby said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com