Sentence examples for be constrained by purifying from inspiring English sources
The functions of the lncRNAs remain largely unknown but their evolution appears to be constrained by purifying selection, albeit relatively weakly.
In addition, genes encoding proteins involved in nucleosome assembly, chromosome organization and proteosome complex also appear to be constrained by purifying selection.
On the one hand they show a remarkable diversity, which indicates that they are shaped by positive selection, but on the other hand they are ancient and have specific targets, suggesting that they are constrained by purifying selection.
Our study suggests that anoctamins have evolved by series of duplication events, and that they are constrained by purifying selection.
The significantly reduced frequency of synonymous SNPs in the UCRs further supports the hypothesis that the synonymous sites in the UCR regions have been constrained by purifying selection.
This is because the evolution of functionally important sequences is constrained by purifying selection (i.e. the removal of deleterious variants).
A common N-terminal topology which includes four highly conserved transmembrane domains is shared by the members of the four paralogous groups of vertebrate bestrophins and has been constrained by purifying selection.
As observed for the Ka/Ks ratio, the distributions of all three nucleotide diversity parameters (Table 7) were right-skewed, suggesting that the majority of E. grandis transcribed regions are constrained by purifying selection.
However, genic microsatellite markers when derived from protein-coding sequences are constrained by purifying selection [ 12] and thus have less potential for revealing polymorphism particularly at the intra-specific level [ 13].
Higher polymorphic potential of UGMS markers derived from the UTRs than that from the conserved coding sequences, which are constrained by purifying selection [ 25, 27] suggested the utility of unigenes having such repeat-motifs as a source of polymorphic microsatellite markers.
