Blood glucose levels were determined from tail blood samples at time zero and then every 15 min. Steady state was reached when glucose measurements were constant for at least 20 min at a fixed glucose infusion rate and was achieved within 30 to 45 min. Plasma insulin concentrations were measured with a radioimmunoassay kit (Insik-5 kit; Diasorin).
Activity tests using the model substrate show that the activity of a reactor that is continuously in operation, is constant for at least two weeks.
Moreover, recurrence continues beyond this time, and the annual rate of local recurrence is constant for at least the first 10 years [ 11].
However, as Figure 1 indicates, the annual incidence of bone metastasis is constant for at least the first 10 years following surgery.
The dilution rate was set to 0.1 h-1 and the cultivation was judged to be at steady state after the carbon dioxide evolution rate had been constant for at least 4 residence times.
The pooled incidence of true local recurrence, new BC in other areas of the ipsilateral breast, and new contralateral BC is constant for at least 15 years [ 11, 12].
Furthermore, that same study reported that although the peak incidence of metastatic disease (the one thing that NICE does not think we should be looking for in follow-up clinics) was in the first 2 or 3 years, the risk for local ('treatable') relapse was constant for at least the first 10 years!
In this article we assume that the effects of a given exposure are evenly distributed in time between the exposure and the lag L (after which no effects occur), and that in the cohort studies, the exposure was constant for at least L years.
Doses of all other concomitant medications or interventions that patients were receiving, including AEDs, vagus nerve stimulation, over-the-counter medications, and herbal supplements (provided that they did not interfere with the metabolism of carbamazepine), must have been constant for at least 14 days prior to the lead-in period and remain so throughout the study period.
We found that the dominance of L4-U otherother Lineage 4 strains and Lineage 3 has been constant for at least the last 18 years, even with episodes of HIV and different interventions such as introduction of anti-retrovirus drugs and promotion of condom use.
